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That said, one likely contributor that stands out in Wisconsin is the multiple, significant tax rate increases the state put in place in 2002, 2008, and 2009, as well as a broad ban on smoking in indoor spaces, including restaurants and bars approved by lawmakers in 2010 (see Figure 1)

This is because it is preferred compared to cigarettes and it is a great alternative

The CHRNA3 rs1051730 genotype had a relatively high F statistic for cumulative and current tobacco consumption in current and former smokers (=strong instrument) and was not associated with any measured potential confounders

Metals like cadmium and lead, along with radioactive elements such as polonium-210, further contribute to cancer risk by creating oxidative stress and additional DNA damage