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Assessing the lung cancer risk reduction potential of cMRTPs before or soon after they are introduced into the market is hampered by (i) the absence of clinical risk markers that are predictive of future lung cancer development, (ii) the latency of lung cancer manifestation (decades of smoking), and (iii) the slow reduction in excess risk upon smoking cessation and a fortiori upon switching to a cMRTP

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Incapsula incident ID: 182000800028954818-113082172473480210

doi:10.3389/fped.2021.647925 31