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Symptoms of head and neck cancer can include: A lump in the neck Change in voice (hoarseness) Growth in the mouth Coughing or bringing up blood Difficulty Swallowing Changes in skin Persistent earache A lump in the neck Cancers that begin in the head or neck usually spread to lymph nodes in the neck before they spread elsewhere

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5 Assessing the cardiovascular threat of nicotine pouches in youth 5.1 Direct evidence (limited) Direct evidence on the cardiovascular effects of nicotine pouches, especially in young people, is scarce