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We found that, even after factoring in the heterogeneity between studies and other sources of uncertainty, smoking has a strong-to-very-strong association with a range of health outcomes and confirmed that smoking is irrefutably highly harmful to human health

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Laden et al

It comes from a 2010 meta-analysis of Social Relationships and Mortality Risk (see Figure), which benchmarked the size of the effect that lacking social connection has on risk for premature mortality against the effect of other known risk factors, including smoking