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In accordance with these results, upregulation of filaggrin was also observed in oral keratinocytes of smokers 19 , in keratinocyte cell cultures 19, 20 or in reconstructed human epidermis 21 exposed to cigarette smoke extract, and porcine skin explants exposed to cigarette smoke (our unpublished data)

Circulation 110(15):22332240 Anton MM et al (2006) Cigarette smoking, regular exercise, and peripheral blood flow

Kaisar MA, Villalba H, Prasad S, Liles T, Sifat AE, Sajja RK, et al

Moreover, different doses of nicotine stimulate different effects (dose-dependent response)

[21] Use under medical supervision and pair with diet, exercise, and behavioral change