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Initiation of tobacco use/ nicotine addiction Carcinogens Tobacco use DNA adducts Metabolic activation Mutations in RAS, P53, and other genes Persistence miscoding Cancer Metabolic detoxication Excretion Repair Normal DNA Apoptosis Figure 3: Conceptual model of smokeless tobacco carcinogenesis Modi ed from reference 72

And in Gus's mind, by using a powerful known carcinogen, he's making a connection that humans can prevent cancer by not smoking

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You should report symptoms like headaches, vision issues and ringing in the ears to your doctor immediately

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