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This may be related to the immunosuppressive effects of nicotine

Particulate matter in secondhand marijuana smoke includes: Ammonia Cadmium Chromium Hydrogen cyanide Lead Mercury Nickel Because cannabis is a plant, it might also be contaminated with mold, insecticides or pesticides that get released when smoked

Addressing mitophagy impairments through targeted therapeutic strategies may offer novel avenues for mitigating mitochondrial dysfunction and its downstream effects on neurodegeneration in AD [352]