cigarette smoking and atherosclerosis Smoking, Cessation, Long-Term Risk of 3 Major Atherosclerotic Diseases Regulation of endothelial function by

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Figure 3 also shows the increase in the intercept (a) of this relationship, which defines the increase in end expiratory lung volume (hyperinflation)

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As a result, smokers often metabolise caffeine faster than non-smokers and often require a higher caffeine intake to achieve the same stimulant effects